Recovery after mesothelioma surgery depends on the procedure and the patient, but it usually takes four to eight weeks. Most patients will feel like they are back to normal within three to four months and can expect to be back to their daily routines in six months.
Written by Karen Selby, RN | Medically Reviewed by Dr. Marcelo DaSilva | Edited by Walter Pacheco | Last Update: April 8, 2025
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Getting better after surgery requires a plan. That means doing physical activity like walking two to three times a day for 30 to 45 minutes. Eating healthy foods like fish (which has omega-3 fatty acids), chicken, fruits and vegetables.
You could also take vitamins each day to help you get better faster. If you had an aggressive surgery, your doctor will give you special instructions just for you that can help make recovery easier.
What can be done to improve recovery from mesothelioma surgery?
[MUSIC PLAYING] If a patient chooses surgery for mesothelioma, they’ll undergo a pleurectomy decortication. And the most important thing for patients afterwards is to walk, to move. And it doesn’t even have to be walking long periods of around the hall. It has to be just even sitting up. We know that even sitting up for two to four hours is equivalent to walking a mile in patients that just had surgery two days prior. So sitting them up and then ambulating even with the chest tubes are the most important aspect that we see. And the idea is not only does it help them stay functional and make sure their muscle mass stays improved and not losing muscle mass, but they can also expand the lung. Part of what we do is we take the pleural lining off of the lung. So the lung leaks a little bit. So it’s kind of not really– it’s leaking air, so it’s not fully expanded. It’s not really doing its full potential, especially if you’re laying in bed. It’s like a shriveled raisin. So if you want it to get expanded, the idea is, the more movement they can do, the quicker the lung can expand, heal, decrease air leak, and then they can recover and go home sooner. And so the idea of ambulation and sitting up are really the two– really to simplify it– are really the mainstays of post-operative care after mesothelioma surgery. [MUSIC PLAYING]
Describe Kim’s mesothelioma surgery and recovery process?
The surgery, first of all, was very difficult and complicated, and it was an all day surgery. Going into the surgery, Kim had a lot of faith that she would make it through. And she had a lot of faith in her surge and doctor Cameron. She really trusted him. She really believed in him. She really knew that she was in great hands with him. She knew that she would come through this procedure and that she would survive it she would recover from it. The hospital staff there were fantastic. They were so attentive. They were so loving, so supportive, so encouraging that she really was in great hands there. Kim’s background is that she’s a registered nurse, and I really think that that helped her through this whole process as well. Because when anybody spoke to her medically about what to expect or what she was gonna be going through, She really already had a really broad knowledge of the procedures. She knew what they were talking about. She knew what their recovery would pretty much be like for her. There were many times when she was recovering in the hospital that she did really well. She was able to gather her strength. She was able to get out of bed. She was able to go on some walks with some assist ins initially. And then later on as her strength felt, she was able to, you know, walk down the halls on her own. And then there were difficult times. The most difficult part of her procedure, I think, with some of the things that she had to do and her recovery. One of the things that doctor Cameron asked her to do was to lean over the cable. It was something that he wanted her to do a couple times a day. And so she would literally take a pillow, put it on the little table and lean over, and it was very difficult for her to do. I mean, I would try to talk to her, sidetracked her, joke around with her, and give her the countdown on how many more minutes seconds, just whatever it her through it. Then there was a nausea. That was really bad. There was times that she just was so nauseous and so sick feeling that, it was very difficult. It was difficult for her. It was difficult. See her to go through that. She had what we call the smelly stick. It was actually the stick that was designed for people going through nausea symptoms. And he literally twisted it. And one of us either I would hold it under her nose she would hold it herself and just try some deep breathing and inhale from this stick to release them in the non and just to help her relax. I knew going into this that Kim would recover that she would make it through this. Kim is very strong. She’s a resilient. She had a will to live. And I think really for her, that was critical. And so even when things got tough, I always knew that she could make it through. And there was a lot of times it was just one fit in front of the other just one treatment, just one, you know, walk down the hall, one, you know, wave of nausea to get through. It was just kind of the process. And she got stronger as her incisions started to heal, and she was getting out of bed and able to do more.
What is the typical timeline for mesothelioma surgery?
[MUSIC PLAYING] When a patient for mesothelioma
comes to see, for example, me, the idea is for initial consultation to assess whether or not they're an operative candidate. And if they are, the idea that I really try to push is that we need to try to do this within four weeks from when we have a diagnosis to even seeing me. And so what that is— that's often harder to do than not, regardless of how close you are, but very doable.
And so the idea is that you have four weeks to get— once you've seen the consultation. If you can get surgery on the schedule into our operating room within four weeks, I think that's a success. If we look at the data— and even when I was before the Brigham— we were seeing a lag time of three to four months before patients were diagnosed and when they actually got their surgery.
And so there's never been a definitive study looking at time to diagnosis and time to surgery outcomes. We do have a study that I've looked at with time for the outcomes for lung cancer. And we found lung cancer— if you're diagnosed with lung cancer, at the time of diagnosis to time of surgery, the most optimal time in terms of the best survival and least amount of recurrence is actually four weeks.
Now, lung cancer is different than mesothelioma. We know that. It's a different disease process. But that's something— a basis that I've been using for, quote, unquote— because for mesothelioma and for lung cancer. So when I do have a consult with the mesothelium patient, we really try to get them in four weeks.
So that means they have the consultation with me virtually. Then they have to get the heart study, the lung study, and the lab work all within four weeks. And then we operate.
Once we operate, the surgery itself, pleurectomy decortication, usually takes about four hours. It's a four-hour surgery that will involve general anesthesia. An epidural will be in place afterwards to help with some of the pain, so to minimize narcotic use.
After the surgery, you're in the hospital from 7 to 12 days. The ICU stay is usually one to two days. And then after that, it's the regular floor, walking around, eating, all that for 7 to 12 days.
Then, after that, it's about four to six weeks total of full recovery. But the majority of patients, more than 90% of patients, will go home. They'll go home as long as they have somebody around, whether it be significant other or family member, to kind of help things out in terms of the cooking and driving.
But after that— so a total of six weeks from the operation is the hardest part of the recovery. And then in terms of long term, it really is another two months, so a total of three months, where they're feeling excellent, per se, and they feel like they're really noticing a lot of the benefits. So that's kind of the time frame that I say.
In terms of starting the chemotherapy, I usually like to start it within four to eight weeks after the day of surgery. That's usually the most optimal time that we try to get that in. But again, there is no data to show if four weeks after surgery versus three months after surgery for chemotherapy is OK.
But preliminarily, when we look at it— patients are further away or some are older and it takes them longer to recover. Say it takes them two or three months to recover after surgery. They can still get their chemotherapy, and we still see a beneficial effect if they get their chemotherapy even later afterwards. [MUSIC PLAYING]
Going through mesothelioma treatment can be a big change in your life. It might help you live longer so that you can have more time to spend with your family and friends. This is the time to gather the support of your family, friends and community.
While experts consider tumor-removing surgery an essential component of multimodality treatment for long-term survival, not every patient qualifies for it. For those who do, the recovery period differs by the type of procedure. Patients who are candidates for pleurectomy/decortication may have an initial prolonged recovery (two to three weeks), but a faster long-term recovery, and those who undergo EPP might have a shorter initial recovery time (seven to ten days), but a prolonged long-term path to recovery.
For most tumor-removing surgeries, a hospital stay of at least two weeks is common. Recovery at home usually is less intensive — but lasts longer — from eight weeks to as long as a year. Any complications along the way might prolong recovery.
Every patient and treatment plan is unique to a patient, so no recovery timeline will be exactly alike. The time it takes to recover fully can vary depending on the stage of your cancer, your overall health and the specific course of treatment.
A treatment plan combining surgery and one or more additional therapies may extend the recovery process. Chemotherapy and radiation therapy can cause fatigue and other undesirable side effects, but otherwise might not interfere with your daily life.
Before you commit to a treatment plan based on your local doctor’s advice, it’s important to familiarize yourself with each treatment option and the recovery phase that lies ahead.
Tumor-removing surgery is significantly more invasive than diagnostic surgery. The goal is to remove as much of the cancer as possible. These surgeries take hours to complete and require a hospital stay of approximately two weeks. Recovery at home depends on the extent of the surgery and may take two months to a year.
Extrapleural pneumonectomy is considered the most aggressive surgery for pleural mesothelioma. It removes the cancerous lung, the diaphragm, nearby lymph nodes and the lining of the heart and lung. EPP patients usually stay in the hospital for seven to ten days. Full recovery from the aggressive EPP procedure usually takes six to eight weeks, but may extend to three to four months.
Pleurectomy and decortication is considered less aggressive than EPP. It removes the lung lining and any parts of the lung, diaphragm, chest wall and heart lining that appear cancerous. Patients who received a P/D should expect a hospital stay of about two weeks. Recovery from the lung-sparing P/D procedure ranges from four to six weeks.
Peritoneal mesothelioma patients often benefit from cytoreductive surgery and heated intraperitoneal chemotherapy (HIPEC). The surgical part of this procedure aims to remove as much cancerous tissue as possible from the abdomen. It removes the lining of the abdomen and parts of organs that appear cancerous such as the stomach, intestines, liver, spleen and pancreas.
Patients can expect a hospital stay of at least two weeks. Recovery from cytoreductive surgery and HIPEC depends on the extent of surgery and ranges from six weeks to a year, but it can add years to life expectancy.
Surgery is also used to diagnose mesothelioma. Diagnostic surgeries are less invasive than surgeries that remove tumors. It takes less time to recover from diagnostic surgery than tumor-removing surgery.
Diagnostic surgeries are minimally invasive and recovery usually takes a few days to a week. These surgeries involve just a small incision to give doctors access to the chest cavity or abdominal cavity. Doctors insert a small tube through the incision to collect tissue or fluid samples, also called biopsies. These samples are tested for signs of cancer.
We coordinate your care with top cancer centers and guide you through every step.
Get Help NowIf you’re healthy enough for mesothelioma surgery, there’s a good chance your doctor will recommend additional treatments before, during or after the procedure. This approach, known as multimodal therapy, currently offers the best hope for long-term survival.
It is important to understand a combined approach to treatment can affect your recovery time. A multimodal therapy plan that incorporates surgery typically lengthens recovery time, but all patients respond to treatment differently.
Multimodal therapy can include any combination of surgery, chemotherapy and radiation therapy as well as experimental treatments such as immunotherapy. The length of your recovery will vary depending on the treatments you choose and how your body reacts to them.
Most chemotherapy is done on an outpatient basis and takes a few hours to complete. Heated chemotherapy requires a hospital stay of a week or more.
Certain side effects may last for weeks or months after your last chemotherapy cycle. For example, peripheral neuropathy, which is a type of nerve pain in the extremities, may develop during or after treatment. The symptoms of peripheral neuropathy may peak three to five months after your last cycle. Pain medication and complementary therapies are available to help people through recovery.
Chemotherapy is a weird thing to describe to people who never lived it. At times, you just don’t feel right, but it’s hard to always pinpoint why. Your body just gets out of sorts.
Chemotherapy can also lead to thinking and memory problems commonly called chemo brain. Chemo brain symptoms typically only last a short time and fade as chemotherapy ends. But some patients experience cognitive dysfunction long after treatment is over, and there are cases where patients never fully regain mental ability.
Side effects can be difficult to manage, so ask your doctor about what to expect and how you can cope. Most patients feel weak or drained after chemotherapy, but the tiredness generally subsides after a few days. Once it passes, you may feel even better than before.
Like chemotherapy, radiation therapy is an ongoing treatment that can drain your energy and cause fatigue. If you opt for radiation therapy, the most common side effects include fatigue and redness, irritation and hair loss around the treatment area.
Radiation therapy for mesothelioma typically lasts four to five weeks, with five 30- to 60-minute sessions each week. Fatigue tends to increase as treatment progresses and then improves after therapy ends. Make sure to get plenty of rest.
Having chemotherapy before or at the same time as radiation therapy can make the skin reaction worse. Your doctor may recommend that you avoid applying soap, lotion, perfume and cosmetics to the treatment area. Talk to your doctor about the best way to care for skin irritation. You will need to schedule regular follow-up appointments with your doctor once treatment ends.
The most important thing for patients after surgery is to walk, to move. And it doesn’t even have to be walking long periods of around the hall. It has to be just even sitting up. We know that even sitting up for two to four hours is equivalent to walking a mile in patients that just had surgery two days prior.
It’s difficult for the body to recover from mesothelioma treatment, particularly when surgery is part of your treatment plan. Regardless of the treatments you receive, there likely will be emotional hurdles to overcome as well.
The days following chemotherapy and radiation therapy may feel exhausting, but as long as you have the energy, you should be able to perform normal daily activities. You need to be more careful with physical activity after major surgery because the recovery process is much longer. A good balance of gentle exercise and rest can help alleviate fatigue from treatment. If you feel pain during any type of activity, stop immediately. You may want to consider meeting with a physical therapist to help regain strength.
While you work on your physical recovery, don’t neglect your emotional needs. Cancer treatment is never easy, and it’s perfectly normal to feel a wide range of difficult emotions, including sadness, anxiousness and fear.
Studies show many cancer patients can achieve a higher quality of life by joining a support group and sharing their feelings and experiences with others. If support groups aren’t for you, there are plenty of other outlets that might fit your situation and personality better. You can also seek emotional support from family, friends, spiritual groups or one-on-one counseling.
Surviving cancer may be one of the greatest challenges you’ll ever face, but you don’t have to face it alone. It’s not easy to stay upbeat throughout treatment, but a positive attitude and a solid support system can help tremendously on the road to recovery.
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Selby, K. (2025, April 8). Recovering From Mesothelioma Surgery. Asbestos.com. Retrieved December 18, 2025, from https://www.asbestos.com/treatment/surgery/recovery/
Selby, Karen. "Recovering From Mesothelioma Surgery." Asbestos.com, 8 Apr 2025, https://www.asbestos.com/treatment/surgery/recovery/.
Selby, Karen. "Recovering From Mesothelioma Surgery." Asbestos.com. Last modified April 8, 2025. https://www.asbestos.com/treatment/surgery/recovery/.
Dr. Marcelo DaSilva is chief of thoracic surgery and medical director at AdventHealth Cancer Institute in Orlando, Florida, where he has built a mesothelioma specialty program.
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