Mesothelioma Risk Factors

Importance of Understanding Risk Factors for Mesothelioma

Risk factors are characteristics that increase your likelihood of developing a particular disease. Many risk factors are associated with an increased chance of developing various diseases.

Malignant mesothelioma is a rare and aggressive type of cancer that can affect the lungs, abdomen, heart and testes. Asbestos causes mesothelioma. However, not everyone exposed to asbestos will develop mesothelioma, and some cases of mesothelioma are due to other causes. Mesothelioma usually develops 20 to 60 years after asbestos exposure; this means that many people are at risk despite the limited use of asbestos today.

Asbestos exposure is the primary risk factor for mesothelioma. Other risk factors include genetic factors, age, gender and other exposures. Some risk factors can be changed, while others cannot. You can decrease your risk of mesothelioma by reducing your asbestos exposure and other environmental exposures. If you have a history of asbestos exposure, your risk of developing mesothelioma increases as you age, but there are other risk factors that you have some control over.

Asbestos Exposure and Other Risk Factors 

Asbestos is a naturally occurring fiber found in six different minerals. Its properties make it useful for fireproofing and insulation in various industries and consumer products. At one time, asbestos was present in everything from oven mitts to ceiling tiles. It was present in many industrial applications requiring heat resistance or insulation. Asbestos is mined and can contaminate other minerals, such as vermiculite and talc deposits. 

The thin asbestos fibers are most dangerous when inhaled, but ingestion and skin contact can also cause asbestos exposure. Asbestos fibers can become airborne due to renovating buildings with asbestos insulation, disturbing asbestos during mining and working with asbestos-containing products.

Any asbestos exposure increases your risk of mesothelioma, but chronic or repeated exposure carries the most significant risk. People who have worked in occupations using asbestos and asbestos-containing materials, such as shipbuilding or asbestos ore processing, tend to have the highest exposure.

Teachers, military personnel and others who have worked in buildings with asbestos can also have high exposure levels. Limited or periodic exposure, such as DIY home renovation or classroom exposure, may carry less risk than direct and repeated exposure over long periods. However, these instances still have the risk of developing mesothelioma.

Occupational Exposure 

Many different industries have a long history of extensive asbestos use. Shipbuilders, steelworkers, construction workers, firefighters, auto mechanics and people who demolish or renovate old buildings all have a significantly increased risk of mesothelioma due to occupational exposure.

Currently, asbestos and asbestos-containing products are limited in the U.S. However, occupational exposure still occurs since asbestos has been present in various industrial and commercial products, such as building materials. People who work in occupations that come into contact with older products, such as brake pads and gaskets, floor and ceiling tiles, fume hoods, and military and firefighting equipment, are at risk of asbestos exposure.

Secondhand Exposure to Asbestos

Secondhand asbestos exposure can affect the families of people who have occupational exposure. Asbestos fibers can be carried from the work site to the home on clothing, shoes, hair and tools. Currently, the limited use of asbestos lowers the chances of secondary exposure. However, the long latency period between exposure and disease means that mesothelioma risk is still high because of past exposure.

Secondhand exposure to asbestos in the home can occur because of family members doing laundry or children hugging a parent. Spouses and children of those with occupational asbestos exposure have an increased risk of mesothelioma stemming from secondhand exposure.

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Environmental Asbestos Exposure

Environmental asbestos exposure can occur during the mining and processing of asbestos-containing ore and disturbance of natural asbestos deposits. Locations, where asbestos is present in the ground or soil, can produce airborne asbestos fibers when they are disturbed by human activity or natural disasters.

Exposure to airborne asbestos can also occur near work sites where asbestos is used or handled. Communities near plants that manufacture asbestos-containing products can have significant exposure and increased mesothelioma risk.

Gender and Age

Men are more likely than women to develop mesothelioma. Men are also more likely to have occupational asbestos exposure, while women are more likely to have secondary exposure. Women are more likely to be exposed to asbestos through contaminated talc used in talcum powder.

Mesothelioma risk increases with age because mesothelioma typically takes 20 to 60 years to develop after exposure. However, this does not mean that young people do not get mesothelioma from asbestos exposure. Cases of asbestos-related mesothelioma have occurred in teens and young adults in their 20s.

Family History and BAP1 Gene

Genetic factors can increase the risk of various types of cancer, including mesothelioma. Your risk of mesothelioma is higher if you have a family history of mesothelioma. 

In most mesothelioma cases, specific mutations of a gene called BRCA-associated protein 1 (BAP1) exist in mesothelioma cancer cells. Mutations are simply variations of the typical DNA sequence of a gene. These mutations can be inherited from a parent or acquired during a person’s lifetime. Mesothelioma is not inherited, but if a person inherits this specific mutation, it will increase their risk of mesothelioma.

Lifestyle and Other Potential Risk Factors 

Lifestyle choices, such as diet and smoking, affect the risk of many diseases, including other types of cancer. Tobacco smoking, diet and nutrition are not risk factors for malignant mesothelioma. 

Smoking is a risk factor for other types of lung cancer; asbestos exposure increases this risk. Diet and nutrition are not risk factors for mesothelioma but can affect the course of the disease.

Simian Virus 40

Simian Virus 40 is a virus linked to several types of cancer, including mesothelioma. SV40 does not usually cause illness in humans and is not known to cause mesothelioma. However, research indicates that many mesothelioma cases show the presence of SV40 in cancer cells. Ongoing research will determine whether it is a risk factor for mesothelioma.

Radiation

Exposure to ionizing radiation may be a risk factor for mesothelioma. X-rays, gamma rays and other forms of ionizing radiation are known to increase the risk of numerous types of cancer. Research shows that low-dose radiation from regular X-rays, CT scans, and occupational exposure are not risk factors. However, exposure to high doses of radiation — such as certain types of radiation therapy for tumors — is believed to be a risk factor for mesothelioma, based on the most recent research.

Who Is Most at Risk for Mesothelioma?

People who have worked in industries with significant occupational exposure to asbestos are at the highest risk for developing mesothelioma. This risk includes veterans and military personnel. Veterans account for 30% of new mesothelioma claims.

Workers in industries that use or have used asbestos are at the highest risk of mesothelioma. Mesothelioma is rare in hobbyists and DIYers, but any amount of asbestos exposure increases your risk of mesothelioma.

Can I Lower My Risk of Mesothelioma?

Reducing asbestos exposure can lower mesothelioma risk. Unfortunately, past asbestos exposure is irreversible. But you can take steps to prevent future exposure.

The risk of occupational asbestos exposure can be lowered by testing and monitoring asbestos levels, using personal protective equipment, following decontamination procedures and having proper training in asbestos safety. If you are at risk of asbestos exposure at work, the Occupational Safety and Health Administration has guidelines and resources to help prevent exposure. Federal whistleblower protection laws protect workers who report possible asbestos exposure against discrimination and reprisal.

Removing asbestos—such as during home renovations—poses a significant risk of exposure. Homes built before 1980 may contain asbestos-containing materials. Do not attempt to remove asbestos yourself. Instead, hire an asbestos abatement professional to test for asbestos, assess exposure risk and adequately remove it. Also, when working on older equipment or purchasing vintage items or reclaimed materials, check to see if they may contain asbestos.

Should I Get Tested for Mesothelioma?

Early diagnosis and treatment of mesothelioma are essential to improve life expectancy. If you have any known asbestos exposure, you should talk to your doctor about it. The Mesothelioma Center can assist you in finding a mesothelioma specialist who can assess your risk of mesothelioma and other asbestos-related diseases. Our Patient Advocates can help you find a specialist and schedule a screening.

Mesothelioma has many of the same symptoms as many other medical conditions. If you are experiencing symptoms and are concerned about possible mesothelioma, our Patient Advocates can help you get a second opinion.

Common Questions About Mesothelioma Risk Factors

How likely am I to develop mesothelioma?

Mesothelioma is a rare form of cancer. There are about 3,100 new cases per year in the U.S. There were 0.7 new cases per 100,000 people in 2018. Mesothelioma is very rare in people without any known asbestos exposure, but asbestos exposure significantly increases those odds.

What are the early warning signs of mesothelioma?

The most common symptoms of mesothelioma are fluid around the lungs, shortness of breath, chest pain, chronic cough and unexplained weight loss. Other cancers, lung disease and heart disease can also cause these symptoms. If you are having any of these symptoms, you should seek medical care.

How much exposure to asbestos will cause mesothelioma?

Most people with asbestos exposure will never develop mesothelioma. However, any asbestos exposure can cause mesothelioma. Chronic exposure carries the highest risk, but even a single exposure can lead to mesothelioma.

What should I do if I’ve been exposed to asbestos?

If you have been exposed to asbestos and are having any symptoms, you should seek medical attention immediately. Mesothelioma can take decades to develop. Even if you are not experiencing symptoms, you should make sure that your doctor knows about your asbestos exposure. Also, learn all you can about asbestos-related diseases. If you know the signs, you can reduce your risk of further exposure.

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