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Written by Karen Selby, RN | Medically Reviewed By Dr. Andrea Wolf | Edited By Walter Pacheco | Last Update: June 27, 2024
The mesothelium is a layer of cells that covers and protects organs and tissue in the body. It also helps regulate response to injury, infection and disease.
Research suggests that it may have other functions, as well. The mesothelium may play a role in transporting fluid and controlling inflammation.
The mesothelium membrane can be distinguished based on the organs or body parts it covers.
Asbestos can harm the mesothelium. Once inhaled or ingested, the toxic fibers become stuck and irritate cells and tissue over time.
Research suggests that the lymphatic system may play a role. With help from the lymph system, fibers may travel to the mesothelium.
Asbestos exposure can cause mesothelioma and other asbestos-related diseases in the mesothelium.
The mesothelium includes two layers.
Mesothelial cells comprise these layers. These cells are a type of epithelial cell. They appear flat and squamous-like.
The primary function of the mesothelium is to provide a protective surface. This surface is flexible and not restrictive of the organs it covers.
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Cancer can develop in the mesothelium after inflammation and scarring. If the damage does not heal, the mesothelium can develop fibrous adhesions. These changes in mesothelial cells lead to malignant mesothelioma and other cancers.
Effusions are the accumulation of fluid between the layers of the mesothelium. They can develop as a result of inflammation and cancer in the mesothelium. Effusions are a symptom of mesothelial diseases, but they are not a primary condition.
Benign and cancerous diseases of the pleura can develop as a result of asbestos exposure.
Benign and cancerous diseases can also develop in the peritoneum.
Asbestos exposure is the primary cause of peritoneal mesothelioma. Peritonitis is inflammation of the peritoneum. Bacterial or fungal infections are the most common causes.
Primary peritoneal serous carcinoma is a type of cancer that can also occur in this area. A 2022 study likened it to advanced-stage serous ovarian carcinoma.
Several benign conditions and cancers can develop in the pericardium.
Benign and cancerous diseases can develop in the tunica vaginalis.
The mesothelium protects organs and responds to inflammation, injury and disease.
Make an appointment with your doctor if you have a history of asbestos exposure and develop abnormal symptoms affecting the lungs, abdomen, heart or testes.
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Selby, K. (2024, June 27). Mesothelium. Asbestos.com. Retrieved October 28, 2024, from https://www.asbestos.com/mesothelioma/causes/mesothelium/
Selby, Karen. "Mesothelium." Asbestos.com, 27 Jun 2024, https://www.asbestos.com/mesothelioma/causes/mesothelium/.
Selby, Karen. "Mesothelium." Asbestos.com. Last modified June 27, 2024. https://www.asbestos.com/mesothelioma/causes/mesothelium/.
A medical doctor who specializes in mesothelioma or cancer treatment reviewed the content on this page to ensure it meets current medical standards and accuracy.
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Dr. Andrea Wolf is the Director of the New York Mesothelioma Program at Mount Sinai in New York City. She focuses on multidisciplinary treatment, clinical research, community outreach and education.
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